Damaging Effects of Long-Term NSAID Use

Indigestion

• Indigestion, also called dyspepsia, is common in people taking NSAIDs for long periods. This usually causes discomfort after meals.
  
  

Ulcers

• Irritation of the stomach and intestinal wall leads to small erosions or ulcers in the lining of the gut.
  
  

Bleeding

• NSAIDs can cause bleeding in the gut that ranges from minimal to life-threatening. Bleeding is the most serious side effect of long-term NSAID use.
  
  

Perforation

• The lining of the gut may become so severely damaged that holes develop. This is a life-threatening complication.
  
  

Heart Disease

• Certain NSAIDs are associated with an increase in heart attacks and strokes. Some of these drugs have been removed from the market.
  
  

Kidney Disease

• Prolonged NSAID use increases the risk of kidney damage, especially when they are combined with certain blood pressure medications.