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- 1). Catch the cold sore in the early stages. Don't ignore the symptoms of a developing cold sore--react immediately.
- 2). Try an over-the-counter topical cold sore medication such as Abreva. Before trying the medication, ask the pharmacist about any possible side effects, and inform the pharmacist of any other medications you are taking. Apply the medication according to the instructions on the packaging.
- 3). Contact your doctor and ask about obtaining a prescription cold sore medication. If the over-the-counter medication does not work for you, you might consider a prescription medication. According to the Mayo Clinic, Denavir is an effective prescription drug to treat cold sores. Apply the medication according to the pharmacist's instructions.
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