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Genetic Test : Health & Medical
GWAS vs Whole-Exome Sequencing: What's the Difference and Why We Should Care
Arguments abound for next-generation sequencing technologies to replace genome-wide association studies, but a pair of studies may breathe new life into the old tried and true.
Parkinson's Disease Pharmacogenomics: New Findings
Can variability in drug response and in complication occurrence with pharmacologic therapies for Parkinson's disease be explained by genetic factors?
CYP2D6 Genotypes and Adjuvant Tamoxifen for Breast Cancer
Do treatment outcomes of tamoxifen for breast cancer differ according to CYP2D6 genotype?
Pharmacogenomics of Carbamazepine: Clinical Implications
Dr. Andrew Wilner reviews current data on the clinical benefit of HLA-B*1502 screening to avoid carbamazepine-related hypersensitivity.
Tumor Angiogenesis Genotyping in Metastatic Gastric Cancer
Tumor angiogenesis genotyping in metastatic gastric cancer patients may help identify a patient subgroup unlikely to benefit from a platinum-based chemotherapeutic regimen.
Alzheimer's Disease and Genetics of Inflammation: A Pharmacogenomic Vision
Inflammation plays a key role in Alzheimer disease, and dissecting the genetics of inflammation may provide an answer to the possible treatment.
Personalized Sequencing and the Future of Medicine
Advances in the speed and scale of DNA sequencing means it's now practical to produce personalized clinical evaluations. What impact will this have on pharmacogenomics and medicine as a whole?
hs-CRP: What Is Proven and Unproven?
Dr. Michael Davidson looks at genetic links between C-reactive protein and cardiovascular disease and considers how these data might influence clinical practice.
Personalized Medicine in Oncology
Despite its promise, actual implementation of personalized medicine into oncology remains limited. What issues still need to be addressed before it can be fully integrated into clinical practice?
Pharmacogenetics of Chronic Obstructive Pulmonary Disease
What insights can pharmacogenetic studies give us as to the various phenotypes of COPD and their differing responses to currently existing and future therapies?
Pharmacogenetics of Childhood Acute Lymphoblastic Leukemia
This review explores the pharmacogenetics surrounding chemotherapeutic protocols in pediatric ALL, with a focus on markers which might predict treatment resistance and toxicity.
Tamoxifen and CYP2D6 Genotypes: Current Clinical Implications
Dr. Maurie Markman reviews current data on the clinical utility of CYP2D6 testing for breast cancer patients taking tamoxifen.
Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC
Does the presence of polymorphisms in certain genes and alterations in their miRNA expression affect in vitro chemosensitivity to cisplatin and gemcitabine?
Is Homocysteine a CHD Risk Factor? The Genetic View
Dr. Michael Davidson discusses how a study looking at a genetic cause of elevated homocysteine levels might explain some of the links between homocysteine, folic acid supplementation, and CHD risk.
Genetic Markers for Alzheimer Disease: Are They Ready for Prime Time?
Dr. Gary Small discusses the potential clinical application of recent findings on cerebrospinal fluid genetic markers for Alzheimer disease.
Variants of Monoaminergic-Related Genes in Geriatric Psychiatry
Why do older adults have varied and complex responses to psychotropic medications?
Pharmacogenomics of Abacavir: Current Clinical Implications
Dr. Daniel Kuritzkes reviews current data on the clinical benefit of HLA-B*5701 testing to prevent abacavir hypersensitivity reaction.
Genetics of Ischemic Stroke and Stroke-related Risk Factors
Will pharmacogenetics open a new era in stroke therapy? This review summarizes candidate gene and genome-wide studies aimed at discovering genetic stroke risk factors and subclinical phenotypes.
Genetic Predictors of Treatment-Induced Viral Clearance in Hepatitis C
Drs. Dermot McGovern and Gil Melmed comment on a study published in Nature on the ability of an IL-28B polymorphism to predict sustained viral response to hepatitis C treatment.
A Urinary Biomarker Associated With CYP2D6 Activity
CYP2D6 is crucial for the metabolism of many drugs, but currently phenotyping requires administration of a probe drug. Could a urinary biomarker provide a noninvasive method of CYP2D6 phenotyping?