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Bleeding Disorders
The fragility of the germinal matrix blood vessels along with the lack of autoregulatory capacity of the cerebral vessels of the brain of sick infant increases the risk of bleeding events in this population. Although the concurrent use of oral sildenafil with other anticoagulant agents can enhance the potential antiaggregatory effect of this drug, its isolated use has not shown any direct effect on the aggregation of human platelets. Case reports of variable hemorrhagic events during oral sildenafil therapy have been loosely linking these events to the use of sildenafil. This AE, however, has not been observed to date.
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